Stephen G Young Selected Research

O(4)-methylthymidine triphosphate

5/2009	Lowering plasma cholesterol levels halts progression of aortic valve disease in mice.
9/2008	Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice.
2/2006	Compensatory increase in hepatic lipogenesis in mice with conditional intestine-specific Mttp deficiency.
5/2004	CD1d function is regulated by microsomal triglyceride transfer protein.
2/2002	Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury.

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Stephen G Young Research Topics

Disease

36	Progeria (Hutchinson Gilford Syndrome) 01/2021 - 07/2004
14	Hypertriglyceridemia 01/2022 - 06/2009
10	Neoplasms (Cancer) 12/2014 - 01/2002
8	Atherosclerosis 12/2020 - 03/2003
8	Lipodystrophy 09/2016 - 07/2004
7	Cardiomyopathies (Cardiomyopathy) 08/2014 - 02/2004
5	Rupture 01/2021 - 10/2018
5	Obesity 11/2018 - 03/2004
5	Muscular Dystrophies (Muscular Dystrophy) 08/2014 - 07/2004
4	Inflammation (Inflammations) 01/2020 - 02/2002
4	Insulin Resistance 11/2018 - 09/2008
4	Premature Aging 10/2018 - 10/2008
4	Blister (Bulla) 10/2018 - 09/2006
4	Hypercholesterolemia 08/2009 - 03/2003
3	Hyperlipidemias (Hyperlipidemia) 01/2022 - 03/2004
3	Inborn Genetic Diseases (Disease, Hereditary) 05/2015 - 09/2011
3	Carcinogenesis 12/2014 - 01/2006
3	Body Weight (Weight, Body) 06/2013 - 04/2006
2	Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris) 11/2017 - 02/2016
2	Colonic Neoplasms (Colon Cancer) 12/2014 - 03/2005
2	Coronary Disease (Coronary Heart Disease) 07/2014 - 07/2008
2	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2014 - 09/2007
2	Bone Fractures (Bone Fracture) 06/2013 - 10/2002
2	Lung Neoplasms (Lung Cancer) 04/2010 - 05/2007
2	Laminopathies 07/2009 - 09/2003
2	Aortic Valve Stenosis (Aortic Stenosis) 05/2009 - 11/2006
2	Emery-Dreifuss Muscular Dystrophy (Scapuloperoneal Muscular Dystrophy) 07/2007 - 09/2006
2	Muscle Weakness 03/2006 - 10/2002
1	Pancreatitis 03/2020
1	Hepatomegaly 01/2020
1	Movement Disorders (Movement Disorder) 01/2019
1	Glioma (Gliomas) 01/2019
1	Atherosclerotic Plaque (Atheroma) 01/2019
1	Dystonia (Limb Dystonia) 01/2019
1	Dystonia musculorum deformans type 1 01/2019
1	Multiple Sclerosis 01/2019
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2018
1	Autoimmune Diseases (Autoimmune Disease) 07/2017
1	Vascular Diseases (Vascular Disease) 01/2017
1	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 01/2017
1	Familial Partial Lipodystrophy (Dunnigan Syndrome) 09/2016
1	Esophageal Achalasia (Megaesophagus) 05/2015
1	Ichthyosis (Xeroderma) 12/2014

Drug/Important Bio-Agent (IBA)

31	prelamin AIBA 10/2018 - 10/2002
15	LaminsIBA 01/2021 - 09/2003
15	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2002
14	Triglycerides (Triacylglycerol)IBA 01/2022 - 03/2004
13	Lamin Type A (Lamin A)IBA 10/2018 - 12/2004
12	LipidsIBA 01/2019 - 04/2005
8	Lipoproteins (Lipoprotein)IBA 01/2022 - 03/2003
8	Lamin Type B (Lamin B)IBA 01/2021 - 09/2003
8	CholesterolIBA 12/2020 - 03/2004
8	lamin CIBA 09/2016 - 07/2005
7	p21(ras) farnesyl-protein transferase (protein farnesyltransferase)IBA 02/2013 - 07/2005
5	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 01/2022 - 07/2014
5	geranylgeranyltransferase type-I (protein geranylgeranyltransferase)IBA 02/2013 - 05/2007
5	O(4)-methylthymidine triphosphateIBA 05/2009 - 02/2002
4	AutoantibodiesIBA 03/2020 - 01/2017
4	EnzymesIBA 01/2020 - 03/2006
4	high density lipoprotein binding proteinIBA 01/2017 - 12/2010
4	Glycosylphosphatidylinositols (Glycosyl-Phosphatidylinositol)IBA 01/2017 - 12/2010
3	ChromatinIBA 01/2021 - 03/2011
3	CytokinesIBA 11/2018 - 02/2013
3	LDL Receptors (LDL Receptor)IBA 02/2013 - 03/2003
3	Apolipoprotein B-100 (Apo B 100)IBA 05/2009 - 11/2006
3	Farnesyltranstransferase (Farnesyltransferase)IBA 01/2008 - 01/2002
2	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 09/2008
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 01/2017
2	HIV Protease InhibitorsIBA 12/2016 - 04/2008
2	SphingolipidsIBA 12/2014 - 09/2012
2	MicroRNAs (MicroRNA)IBA 12/2014 - 08/2014
2	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 12/2014 - 09/2012
2	lipineIBA 07/2013 - 09/2012
2	protein-S-isoprenylcysteine O-methyltransferaseIBA 06/2013 - 03/2005
2	Insulin (Novolin)FDA Link 01/2013 - 09/2008
2	Transaminases (Aminotransferases)IBA 01/2012 - 02/2002
2	Apolipoproteins AIBA 12/2010 - 04/2005
2	Superoxides (Superoxide)IBA 05/2009 - 11/2006
2	ras ProteinsIBA 08/2008 - 01/2006
2	LDL CholesterolIBA 07/2008 - 03/2003
2	Apolipoproteins B (ApoB)IBA 03/2008 - 03/2003
1	Small Interfering RNA (siRNA)IBA 01/2021
1	PhytolIBA 01/2020
1	SiliconIBA 12/2019
1	InterferonsIBA 01/2019
1	Adenosine Triphosphatases (ATPase)IBA 01/2019
1	Phenobarbital (Luminal)FDA Link 01/2019
1	AAA ProteinsIBA 01/2019
1	Interleukin-10 (Interleukin 10)IBA 11/2018
1	Interleukin-10 ReceptorsIBA 11/2018
1	GPI-Linked ProteinsIBA 01/2018
1	Antinuclear AntibodiesIBA 07/2017
1	Pharmaceutical PreparationsIBA 12/2016
1	AntibodiesIBA 09/2016
1	Lopinavir FDA Link 09/2016
1	Monoclonal AntibodiesIBA 09/2016
1	Nonsense Codon (Nonsense Mutation)IBA 02/2016
1	sphingosine 1-phosphate lyase (aldolase)IBA 12/2014

Therapy/Procedure

3	Therapeutics 01/2019 - 07/2009
1	Oral Administration 12/2014